O Microfluidic Cell Culture Analog Devices to Mimic Animal exposures to Toxins and drugs CNF Project
نویسندگان
چکیده
Our group has developed microfluidic in vitro devices that mimic the response of humans or animals to drugs, toxins, or nanoparticles. Each device, or cell culture analog (CCA), contains an array of pseudo tissues that are interconnected by microfluidic channels [1]. The recirculation of blood surrogate through the microchannels allows us to study tissuetissue interactions, such as the breakdown of a parent compound in the liver and subsequent transport and reaction in the lung. We combine these in vitro device experiments with physiologically-based pharmacokinetic model simulations to predict toxin and drug dynamics in humans [2].
منابع مشابه
Microfluidic Cell Culture Analog Devices to Mimic Animal Exposures to Toxins and Drugs
We have developed several in vitro systems to predict human and animal responses to chemical exposures. These cell culture analogs (CCAs) are fabricated in silicon or polystyrene, and contain cell culture chambers connected with microfluidic channels. The cell chambers are designed to mimic animal tissues, with chamber size and culture medium flow rate scaled to match corresponding organ size a...
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